Please e-mail us your questions or suggestions to
one@dietcancer.com

FASEB Journal (1995) 9(4):A9889.

Dual protective mechanisms of sodium butyrate and benzyl isothiocyanate in human colon cells: induction of detoxification enzymes and apoptosis.
Kirlin WG DeLong MJ  Jones DP.
Emory University Sch. Medicine and Sch. Public Health. Atlanta GA 30322

ABSTRACT
The positive association of fruit and vegetables intake with lower incidences of colon cancer is thought to be due to the presence of  both fiber and chemical inducers of NAD(P)H: quinone reductase (N:QR) and glutathione S-transferase (GST). A protective effect of fiber is  production of butyric acid by microflora, which promotes cell differentiation... Cells lifting showed apoptotic  characteristics of chromatin condensation and DNA fragmentation.  These findings suggests a dual mechanism for cancer prevention by NaB  and BIT. NaB enhances the effectiveness of dietary compounds, such as  BIT, to induce detoxification enzymes and both promote the rate of apoptosis of damaged cells.

               Next Abstract (7)   Selected Sections   Main Page