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BIOCHEMICAL RATIONALE TO ADVOCATE A DIETARY INTERVENTION STRATEGY IN THE TREATMENT OF ADVANCED CANCER. Previous studies These studies have uniformly concluded that there are more than five hundred identified, and thousands still unidentified, molecular structures and biological factors present in fruit and vegetables with very significant cancer preventive and cancer chemotherapeutic activities. There is also today, a wider scientific knowledge about specific carcinogenic substances present in food and in the environment. There are a number of recommendations on how to avoid these substances that can produce direct mutagenic damage to our cells and tissues. Design of a Dietary Intervention Strategy We can design, for example, a dietary intervention, low in the ingestion of heterocyclic amines and high in isocyanates. A recommendation to decrease ingestion of heterocyclic amines will be based on the 560 peer reviewed published reports confirming the strong mutagenic and carcinogenic effects of heterocyclic amines. Some of them are produced after cooking meat at high temperatures. The dietary recommendation to increase food products high in isocyanates will be based on the 212 peer reviewed publications relating to isocyanates with tumour regression and cancer preventive activities. Scientific Information 1. –More than 300 epidemiological studies on large populations investigating serum level constituents and consumption averages of the related foods. 2. – More than 5000 animal and in-vitro studies in which claims as to the anti-tumour activity of naturally occurring compounds have been analysed and subjected to full scrutiny. 3. – Hundreds of clinical trials in which the intrinsic properties of specific natural compounds have been tested for their preventive and chemotherapeutic effects on cancer. The days in which dietary interventions were considered a branch of Alternative Medicine are now over. There is today enormous scientific background knowledge on this field, enough to include dietary interventions for cancer, as a part of mainstream orthodox medicine. The Carcinogenic Process When a few cells mutate into a cancerous state, anti-tumour molecules, found normally at various concentrations in the blood serum, exert a chemopreventive effect, activating the cell’s DNA repair mechanism, inducing cell differentiation and impeding the advance of proliferation. Anti-tumours actiuvity If there are not enough of the above mentioned anti-tumour complexes present in the circulatory system to exert a chemopreventive function, the cancer cells will start to proliferate freely. When millions of abnormal cells form a solid tumour mass, chemoprevention by itself will not be effective. However, if the same substance, effective as a chemopreventive agent, at micromolar concentrations in serum, can be amplified enough, this chemopreventive activity translates into a chemotherapeutic effect. As a result of increasing the above anti-tumour complexes circulating in serum, to higher than normal levels, an active anti-tumour response develops. Anti-Tumour Effect Amplification. Each different form of cancer can advance freely when there is a serum deficiency of a specific anti-tumour complex needed to fight that type of tumour. Moreover, each patient, in accordance with his own nutritional lifestyle, can develop a different type of anti tumour molecular- complex serum deficiency. If the ratio between the serum deficiency and the specific form of anti-tumour activity required to induce tumour regression can be determined, a strategy to attack the tumour and metastasis by natural means can then be established. Characterising, isolating and concentrating natural anti-tumour substances, has provided us with the basic tools to design dietary intervention strategies for many cases of advanced cancer. Factor Gimmel Factor Gimmel dimensions and ratio differ from patient to patient and constitute the differential element looked for when designing anti-tumour dietary intervention strategies to treat cancer. Evidence obtained thus far, with patients that have agreed to follow dietary intervention recommendations, has been very encouraging. MRI and CT Scans These include patients in which the main tumour focus consisted of: CT., Ultra- Sound and MRI scans done at intervals of five weeks, while intensive dietary interventions have been taking place, resulted in a consistent decrease in the size and number of malignant focuses. This has been an encouraging outcome because, in all these cases, chemotherapy and radiotherapy had already failed to produce any further anti-tumour responses.
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